Methyl 2-cyano-3,3-bis(methylsulfanyl)prop-2-enoate → HCID 178503357, Verbindung

HRID 1830574Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1830574
C[O:2][C:3](=O)[C:4]([C:10]#[N:11])=[C:5](SC)[S:6][CH3:7].[NH2:13][C:14]1[CH:18]=[CH:17][NH:16][N:15]=1>C(O)C>[OH:2][C:3]1[N:15]2[N:16]=[CH:17][CH:18]=[C:14]2[N:13]=[C:5]([S:6][CH3:7])[C:4]=1[C:10]#[N:11]

Komponenten

4

Edukt 2

HCID 319957Methyl 2-cyano-3,3-bis(methylsulfanyl)prop-2-enoateHCID 178418806HCID 178418806, Verbindung

Produkt 1

HCID 178503357HCID 178503357, VerbindungAusbeute 55,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3.0 g of 2-cyano-3,3-bismethylthio-2-propenoic acid methyl ester, 1.3 g of 3-aminopyrazole and 20 ml of ethanol were stirred under reflux with heating for about 2.5 hours and then cooled to room temperature, and the precipitated crystals were collected by filtration. The collected crystals were washed with ethanol and then dried to obtain 1.69 g of 7-hydroxy-5-methylthiopyrazolo[1,5-a]pyrimidine-6-carbonitrile (compound No. 49) having a melting point of over 250° C.

Aufarbeitung

  1. temperatureunder reflux
  2. temperaturewith heating for about 2.5 hours
  3. filtrationthe precipitated crystals were collected by filtration
  4. washThe collected crystals were washed with ethanol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-86c70814f5e847279193fce5091cc57e
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067520B2

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