Phosphate → Methyl-phenyl-carbamic Acid 4-(4-chloromethyl-thiazol-2-yl)-phenyl Ester

HRID 1831103Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1831103
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[S:6][CH:7]=1.[CH3:15][N:16]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:17](Cl)=[O:18].P([O-])([O-])([O-])=O>>[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][C:17](=[O:18])[N:16]([CH3:15])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:10][CH:9]=2)[S:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 1061PhosphateHCID 77969Carbamic chloride, N-methyl-N-phenyl-HCID 6055044-[4-(Chloromethyl)-1,3-thiazol-2-yl]phenol

Produkt 1

HCID 10172371Methyl-phenyl-carbamic Acid 4-(4-chloromethyl-thiazol-2-yl)-phenyl Ester

Versuchsvorschrift

The title compound was prepared from 4-(4-chloromethyl-thiazol-2-yl)-phenol and N-methyl-N-phenylcarbamoyl chloride. The aqueous phase was adjusted to PH 7.0 (phosphate buffer) before extraction with ethyl acetate. The crude product was subjected to preparative HPLC (21%, white crystals). HPLC-MS m/z=359.0 (M+1), Rt: 4.60.

Aufarbeitung

  1. extractionbefore extraction with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-5baaf7edaa4b4e028643d510fc725e02
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067517B2

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