1-(Cyclopropylmethyl)piperazine → 4-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester

HRID 1831382

Reaktionsgleichung

Reaktionsgleichung von HRID 1831382
[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:3][CH2:2]1.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](=[O:29])[NH:22][CH2:23][CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:17][CH:16]=1)=[O:13]>ClCCl>[CH3:26][C:25]([CH3:28])([CH3:27])[CH2:24][CH2:23][NH:22][C:21]([C:18]1[CH:17]=[CH:16][C:15]([O:14][C:12]([N:8]2[CH2:9][CH2:10][N:5]([CH2:4][CH:1]3[CH2:3][CH2:2]3)[CH2:6][CH2:7]2)=[O:13])=[CH:20][CH:19]=1)=[O:29]

Komponenten

4

Edukt 2

HCID 9658751-(Cyclopropylmethyl)piperazineHCID 220478734-(3,3-Dimethyl-butylcarbamoyl)-phenyl chloroformate

Produkt 1

HCID 695182864-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The title product was prepared from 1-cyclopropylmethylpiperazine (0.35 mmol) dissolved in dichloromethane (5 ml). 4-(3,3-dimethyl-butylcarbamoyl)-phenyl chloroformate (0.35 mmol) was added at room temperature. The reaction mixture was stirred for 16 h and evaporated to dryness and subjected to preparative HPLC (metod C) (5%, white crystals). HPLC-MS m/z=388.2 (M+1), Rt: 2.43 min.

Aufarbeitung

  1. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-59504eb48063441e9cb20cafdc7b4133
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067517B2

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