[2-Chloro-4-(trifluoromethyl)phenyl]boronic acid → 2-Benzyloxy-4-(2-chloro-4-trifluoromethyl-phenyl)-3-nitro-pyridine

HRID 1831562Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1831562
[CH2:1]([O:8][C:9]1[C:14]([N+:15]([O-:17])=[O:16])=[C:13](Cl)[CH:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:21]=1B(O)O>>[CH2:1]([O:8][C:9]1[C:14]([N+:15]([O-:17])=[O:16])=[C:13]([C:21]2[CH:22]=[CH:23][C:24]([C:26]([F:29])([F:28])[F:27])=[CH:25][C:20]=2[Cl:19])[CH:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 2783251[2-Chloro-4-(trifluoromethyl)phenyl]boronic acidHCID 220520652-(Benzyloxy)-4-chloro-3-nitropyridine

Produkt 1

HCID 220521492-Benzyloxy-4-(2-chloro-4-trifluoromethyl-phenyl)-3-nitro-pyridineAusbeute 79 %

Versuchsvorschrift

2-Benzyloxy-4-chloro-3-nitro-pyridine (Wilde, et al. WO 99/01454, which is incorporated herein by reference in its entirety) (2.0 g, 7.56 mmol) and 2-chloro-4-trifluoromethylphenylboronic acid (2.31 g, 11.3 mmol) were treated substantially as described in Part A of Example 19a to give 2.44 g (79%) of 2-benzyloxy-4-(2-chloro-4-trifluoromethyl-phenyl)-3-nitro-pyridine: MS (AP) m/z 408.8 [(M+H)+, 72].

Aufarbeitung

  1. additionwere treated substantially

Quellen und Nachweise

ORD-Eintrag
ord-8b67b7531c8b4dfab5a7bd7efc393661
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067658B2

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