Sodium Dithionite → 4-(2-chloro-4-trifluoromethyl-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium Dithionite	HCID 24489	—
Edukt	[4-(2-Chloro-4-trifluoromethyl-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine	HCID 22052174	—
Produkt	4-(2-chloro-4-trifluoromethyl-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine	HCID 69658046	78%

Reaktionsschritte

[4-(2-Chloro-4-trifluoromethyl-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine (0.40 g, 1.0 mmol) and Na2S2O4 (1.39 g, 8.0 mmol) were treated substantially as described in Part E of Example 9 to yield 0.29 g (78%) of 4-(2-chloro-4-trifluoromethyl-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine: MS (AP) m/z 373.8 [(M+H)+, 100].

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07067658B2
Quelldatensatz	uspto-grants-2006_06
ORD ID	ord-b7befaffeb084babb4395e25a5026d54
Quellennotiz	uspto-grants-2006_06