Thionyl Chloride → Ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

HRID 1833453Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1833453
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][S:8][CH:9]([CH2:21][CH2:22][CH2:23][CH:24]([O:30][C:31](=[O:33])[CH3:32])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>C1C=CC=CC=1>[Cl:3][CH2:6][CH2:7][S:8][CH:9]([CH2:21][CH2:22][CH2:23][CH:24]([O:30][C:31](=[O:33])[CH3:32])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 21317600HCID 21317600, Verbindung

Produkt 1

HCID 21317532Ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

Thionyl chloride (13.1 g., 0.11 mole) is added dropwise with stirring to a solution of ethyl 8-(2-hydroxyethylthio)-12 -acetoxyheptadecanoate (43.2 g., 0.10 mole) in benzene (150 ml.). The solution is heated at reflux for 2 hours. Then, the solvent and excess thionyl chloride are removed by evaporation in vacuo to leave the title compound as an orange yellow residual oil.

Aufarbeitung

  1. temperatureThe solution is heated
  2. temperatureat reflux for 2 hours
  3. customThen, the solvent and excess thionyl chloride are removed by evaporation in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-83aeadf1aed448cda60418b5030e5abd
Quelldatensatz
uspto-grants-1978_01
Patentnummer
US04066675

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