Dimethylformamide → 2-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

HRID 1833830Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1833830
[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1.CN(C)C=O.S(Cl)([Cl:22])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:13])[C:10]([Cl:22])=[O:11])=[CH:6][CH:5]=[C:4]([Cl:14])[N:3]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 129061732-[(2,6-Dichloropyridin-3-yl)oxy]propanoic acid

Produkt 1

HCID 129061742-[(2,6-Dichloropyridin-3-yl)oxy]propanoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

23.6 g (0.1 mole) of 2-[(2,6-dichloro-3-pyridyl)oxy]-propionic acid, 150 ml of chloroform and 1.5 ml of dimethylformamide are heated with stirring to 55°, and in the course of 1 hour a solution of 18 g (0.15 mole) of thionyl chloride in 40 ml of chloroform is added dropwise. The reaction mixture is subsequently refluxed for 16 hours and is afterwards concentrated in vacuo. The product obtained is used directly for further reactions.

Aufarbeitung

  1. temperatureThe reaction mixture is subsequently refluxed for 16 hours
  2. concentrationis afterwards concentrated in vacuo
  3. customThe product obtained

Quellen und Nachweise

ORD-Eintrag
ord-44bb6621ad28421f8c8cf23cd617d584
Quelldatensatz
uspto-grants-1978_01
Patentnummer
US04067725

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