Dichloromethane → HCID 70617081, Verbindung

HRID 1834072Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1834072
Cl[CH2:2]Cl.[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6].O.S([O-])([O-])(=O)=O.[Mg+2]>C(N(CC)CC)C>[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6].[CH2:14]([N:11]([CH2:10][CH3:29])[CH2:12][CH3:2])[CH3:13]

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 24083Sulfuric acid magnesium salt (1:1)HCID 7061048122202-75-1

Produkt 1

HCID 70617081HCID 70617081, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To 100 ml. of dichloromethane were added 4.2 g. of cephaloglycin monohydrate, 3.0 g. of anhydrous magnesium sulfate, and 2.1 ml. of triethylamine and after stirring the mixture for one hour at room temperature, magnesium sulfate was filtered off to provide a dichloromethane solution of cephaloglycin triethylamine salt. The solution was cooled to -30° C. and then 1.75 g. of 4-oxo-4H-thiopyran-3-carbonyl chloride and 2.1 ml. of triethylamine were added to the solution followed by stirring for one hour.

Aufarbeitung

  1. filtrationmagnesium sulfate was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-0fddaa58609e4d1bb846840700c6665a
Quelldatensatz
uspto-grants-1978_01
Patentnummer
US04068074

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