Dichloromethane → Cephaloglycin

HRID 1834075Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1834075
C(Cl)Cl.[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6].O.S([O-])([O-])(=O)=O.[Mg+2]>C(N(CC)CC)C>[CH3:4][C:5]([O:7][CH2:8][C:9]1[CH2:28][S:27][C@@H:12]2[C@H:13]([NH:16][C:17]([C@H:19]([NH2:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[C:14](=[O:15])[N:11]2[C:10]=1[C:29]([OH:31])=[O:30])=[O:6]

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 24083Sulfuric acid magnesium salt (1:1)HCID 7061048122202-75-1

Produkt 1

HCID 19150Cephaloglycin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

After stirring 35 ml. of a methylene chloride solution containing 2.12 g. of cephaloglycin monohydrate, 1.5 g. of anhydrous magnesium sulfate, and 1.4 ml. of triethylamine for one hour at room temperature, magnesium sulfate was filtered off to provide a solution of triethylamine salt of cephaloglycin. After cooling the solution to -25° C., 816 mg. of 2-imidazolidone-1-carboxylic acid chloride and further 0.3 ml. of triethylamine were added thereto.

Aufarbeitung

  1. filtrationmagnesium sulfate was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-30755719325545ef874dc2b560e95ab6
Quelldatensatz
uspto-grants-1978_01
Patentnummer
US04068074

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