Potassium Iodide → (1-Oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetonitrile

HRID 1834702Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1834702
[CH2:1]([CH:3]1[CH2:11][C:10]2[C:5](=[C:6]([Cl:14])[C:7]([Cl:13])=[C:8]([OH:12])[CH:9]=2)[C:4]1=[O:15])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:23][C:24]#[N:25].[I-].[K+]>CC(C)=O>[O:15]=[C:4]1[C:5]2[C:10](=[CH:9][C:8]([O:12][CH2:23][C:24]#[N:25])=[C:7]([Cl:13])[C:6]=2[Cl:14])[CH2:11][CH:3]1[CH2:1][CH3:2]

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 128572202-Ethyl-5-hydroxy-6,7-dichloroindanone

Produkt 1

HCID 12395624(1-Oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 2-ethyl-5-hydroxy-6,7-dichloroindanone (24.5 g., 0.1 mole), anhydrous potassium carbonate (13.8 g., 0.10 mole), chloroacetonitrile (7.55 g., 0.10 mole) and potassium iodide (1.66 g.) in acetone (0.5 1.) is refluxed for 18 hours. The product which precipitates upon addition of water to the reaction mixture (20 g., 71%) melts at 139°-141° C. after recrystallization from butyl chloride.

Aufarbeitung

  1. temperatureis refluxed for 18 hours
  2. customThe product which precipitates upon addition of water to the reaction mixture (20 g., 71%) melts at 139°-141° C.
  3. customafter recrystallization from butyl chloride

Quellen und Nachweise

ORD-Eintrag
ord-5444567670a0471abf9e9eadd3f63aea
Quelldatensatz
uspto-grants-1978_01
Patentnummer
US04070539

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