HCID 69712066, Verbindung → Ethanone, 1-[(1R,6S)-2,2,6-trimethylcyclohexyl]-, rel-

HRID 1835061

Reaktionsgleichung

Reaktionsgleichung von HRID 1835061
[CH3:1][C:2]1([CH3:12])[CH2:7][CH2:6][CH2:5][C@H:4]([CH3:8])[CH:3]1[C@H:9]([OH:11])[CH3:10].[H][H]>[Cr].[Cu]>[CH3:10][C:9]([C@@H:3]1[C@@H:4]([CH3:8])[CH2:5][CH2:6][CH2:7][C:2]1([CH3:1])[CH3:12])=[O:11]

Komponenten

4

Edukt 2

HCID 69712066HCID 69712066, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 11147955Ethanone, 1-[(1R,6S)-2,2,6-trimethylcyclohexyl]-, rel-Ausbeute 90,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 9833946Chromium, compd. with copper (1:1)Katalysator

Versuchsvorschrift

The (1R,6S)-l-(2,2,6-trimethylcyclohexyl)-ethan-1-ol (15b) (250 g) synthesized in Reference Example 4 and a copper-chromium catalyst (12.5 g) pre-activated with hydrogen were placed in a 500 ml, 4-necked flask equipped with a thermometer, condenser and stirrer, followed by reacting at 200° C. for 6 hours. After cooling the reaction mixture and filtering out the catalyst, the reaction liquid was distilled with a Widmer distiller to obtain 224 g of (1R,6S)-2,2,6-trimethylcyclohexyl methyl ketone (1b) (b.p.: 76-78° C./1197 Pa (9 torr)).

Aufarbeitung

  1. customequipped with a thermometer, condenser and stirrer
  2. temperatureAfter cooling the reaction mixture
  3. filtrationfiltering out the catalyst
  4. customthe reaction liquid
  5. distillationwas distilled with a Widmer distiller

Quellen und Nachweise

ORD-Eintrag
ord-3ec1223ba8454f5796134c2435aef5f2
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06770618B2

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