Hydrochloric Acid → 3-(Thien-2-yl)benzoic acid
Reaktionsgleichung
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[CH:8]=[CH:9][CH:10]=1)=[O:4].[OH-].[Na+].Cl>CO.O1CCCC1>[C:3]([C:5]1[CH:6]=[C:7]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[CH:8]=[CH:9][CH:10]=1)([OH:4])=[O:2]Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
To a solution of 2-(3-methoxycarbonylphenyl)thiophene (1.29 g) in methanol (15 ml) and tetrahydrofuran (5 ml) was added an aqueous solution of sodium hydroxide (1N, 8.87 ml) followed by stirring for 2 hours at 60° C. To the mixture was added hydrochloric acid (1N, 10 ml). The resulting precipitate was collected by filtration and dried to give 2-(3-carboxyphenyl)thiophene (1.13 g, 93.4%).
Aufarbeitung
- filtrationThe resulting precipitate was collected by filtration
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-2ae6f0e1d28e47dd86c0fe3a409b7781
- Quelldatensatz
- uspto-grants-2004_08
- Patentnummer
- US06770667B1
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