Hydrochloric Acid → 4-Bromo-2-(4-hydroxy-phenyl)-benzofuran-5-ol

HRID 1836048Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1836048
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:11]=3[CH:12]=2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].C1C(=O)N([Br:31])C(=O)C1.Cl>CC#N>[Br:31][C:13]1[C:11]2[CH:12]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=3)[O:9][C:10]=2[CH:16]=[CH:15][C:14]=1[OH:17]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 67184N-bromobutanimideHCID 6569362-(4-Hydroxy-phenyl)benzofuran-5-OL2×

Produkt 1

HCID 222215874-Bromo-2-(4-hydroxy-phenyl)-benzofuran-5-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

A solution of 75 2-(4-Hydroxy-phenyl)-benzofuran-5-ol (0.65 g, 2.9 mmol) in CH3CN (40 mL) was treated with K2CO3 (1 g, 7.1 mmol) followed by portionwise addition of NBS (0.36 g, 2.0 mmol). After stirring for approximately 30 minutes, the reaction was worked up by addition of 2 N HCl followed by 10% Na2SO3aq. and then the CH3CN was stripped off. The aqueous layer was extracted with EtOAc and washed with brine and dried over MgSO4. The reaction mixture was concentrated and chromatographed on silica gel (EtOAc/hexanes; 1:4): Mp 196-198° C.; 1H NMR (DMSO-d6) δ 9.93 (br s, 2 H), 7.76 (d, 2H, J=8.5 Hz), 7.40 (d, 1 H, J=8.7 Hz), 7.04 (s, 1 H), 6.87 (dd, 2 H, J=9.0 Hz, 3.1 Hz); MS 305/307 (M+H)+.

Aufarbeitung

  1. extractionThe aqueous layer was extracted with EtOAc
  2. washwashed with brine
  3. dry with materialdried over MgSO4
  4. concentrationThe reaction mixture was concentrated
  5. customchromatographed on silica gel (EtOAc/hexanes; 1:4)

Quellen und Nachweise

ORD-Eintrag
ord-ea23d9bba5db4d22b1cfee2002d53ebe
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06774248B2

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