N-Acetyl-L-Cysteine → Bis-(2-Acetylamino-2-Carboxyethylthio)succinimidyl Hexane

HRID 1836167Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1836167
C1(=O)N([CH:6]([N:12]2[C:16](=[O:17])[CH:15]=[CH:14][C:13]2=[O:18])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])C(=O)C=C1.[C:21]([NH:24][C@H:25]([C:28]([OH:30])=[O:29])[CH2:26][SH:27])(=[O:23])[CH3:22]>N1C=CC=CC=1>[C:21]([NH:24][CH:25]([C:28]([OH:30])=[O:29])[CH2:26][S:27][C:6]([S:27][CH2:26][CH:25]([C:28]([OH:30])=[O:29])[NH:24][C:21](=[O:23])[CH3:22])([N:12]1[C:13](=[O:18])[CH2:14][CH2:15][C:16]1=[O:17])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])(=[O:23])[CH3:22]

Komponenten

4

Edukt 2

HCID 12035N-Acetyl-L-CysteineHCID 18179261Bismaleimidohexane

Produkt 1

HCID 86759503Bis-(2-Acetylamino-2-Carboxyethylthio)succinimidyl Hexane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

Bis-maleimidohexane (0.05 g, 1.81×10−4 mol) and N-acetylcysteine (0.059 g, 3.62×10−4 mol) were dissolved in pyridine (1 ml). The reaction was stirred at 40° C. for 24 h. The solvent was removed in vacuo and the residue was dissolved in ethanol (5 ml) and the solvent removed in vacuo. This procedure was repeated 3 times more. The residue of the title compound weighed 0.1 g.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in ethanol (5 ml)
  3. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-06f1138f7d554dd480ee86b535a46701
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06777190B1

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