Pyridine → 1-Methyl-3-[2-(2-hydroxy-1,1-dimethylethyl)-6-nitro-1,2,3,4-tetrahydroquinolin-4-yl]-urea

HRID 1836312

Reaktionsgleichung

Reaktionsgleichung von HRID 1836312
[NH2:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[NH:5][CH:4]([C:15]([CH3:19])([CH3:18])[CH2:16][OH:17])[CH2:3]1.CS[N:22]=[C:23]=[O:24].N1C=CC=C[CH:26]=1>>[CH3:26][NH:22][C:23]([NH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[NH:5][CH:4]([C:15]([CH3:19])([CH3:18])[CH2:16][OH:17])[CH2:3]1)=[O:24]

Komponenten

4

Edukt 3

HCID 1049PyridineHCID 21933440MethylthioisocyanateHCID 234992302-(4-Amino-6-nitro-1,2,3,4-tetrahydroquinolin-2-yl)-2-methylpropan-1-ol

Produkt 1

HCID 234992231-Methyl-3-[2-(2-hydroxy-1,1-dimethylethyl)-6-nitro-1,2,3,4-tetrahydroquinolin-4-yl]-urea

Versuchsvorschrift

The compound of Example 22 (50 mg) and 30 mg of methyl thioisocyanate were dissolved in 1 ml of pyridine. After 2 hours of stirring at room temperature, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent; hexane:ethyl acetate=1:2) to obtain 42 mg of the title compound. Its physical properties are shown below.

Aufarbeitung

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (elution solvent; hexane:ethyl acetate=1:2)

Quellen und Nachweise

ORD-Eintrag
ord-5f5fe1c04f1041d3a3b0e8a83a2192bf
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06777427B2

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