o-Fluorobenzaldehyde → 2-Fluorobenzaldehyde o-methyloxime
Reaktionsgleichung
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[O:11]([NH2:13])[CH3:12]>>[CH3:12][O:11][N:13]=[CH:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[F:1]Komponenten
3
Versuchsvorschrift
Reaction of 2-fluorobenzaldehyde with methoxylamine hydrochloride as described in the preparation of compound 3-A gave the title oxime ether as a clear oil (98% yield). HPLC indicated a 91:9 mixture of E- and Z-isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): (E-isomer) 3.99 (3H, s, OCH3), 7.07 (1H, m, aromatic), 7.14 (1H, m, aromatic), 7.34 (1H, m, aromatic), 7.82 (1H, m, aromatic), 8.31 (1H, s, CH).
Quellen und Nachweise
- ORD-Eintrag
- ord-a3a2a76cc9af4805adbdb7021b8c75b0
- Quelldatensatz
- uspto-grants-2004_08
- Patentnummer
- US06777440B2
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