Ethyl bromoacetate → HCID 178473177, Verbindung

HRID 1836732Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1836732
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([OH:8])[CH3:7].[Br:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]>C(#N)C>[Br-:9].[CH2:14]([O:13][C:11](=[O:12])[CH2:10][SH:1]1[CH:5]=[CH:4][NH+:3]=[C:2]1[CH:6]([OH:8])[CH3:7])[CH3:15]

Komponenten

4

Edukt 2

HCID 7748Ethyl bromoacetateHCID 99892951-(1,3-Thiazol-2-yl)ethan-1-ol

Produkt 1

HCID 178473177HCID 178473177, VerbindungAusbeute 78,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 1-(2-thiazolyl)ethanol (1.17 g, 8.67 mmole) and ethyl bromoacetate (1.32 g, 8.63 mmole) was heated at 48 C. for 18 hr. The reaction mixture was dissolved in acetonitrile (3 mL) and stored at 4 C. After 2 months the crystals which separated were filtered out and washed with 3:7 ether-acetonitrile to yield 2.028 g of the title compound, mp 101-103 C.

Aufarbeitung

  1. temperaturewas heated at 48 C
  2. customAfter 2 months the crystals which separated
  3. filtrationwere filtered out
  4. washwashed with 3:7 ether-acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-18318557348147dfa7f92c4c749e9a23
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06777557B2

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