N-Allylcyclohexylamine → n-Allyl-n-cyclohexyl-5-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-2-isopropylbenzamide

HRID 1836818

Reaktionsgleichung

Reaktionsgleichung von HRID 1836818
[CH2:1]([N:4]([CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1)[C:5](=[O:34])[C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH:20]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:14][CH2:13]2)[CH:9]=[CH:8][C:7]=1F)[CH:2]=[CH2:3].F[C:42]1[CH:50]=CC([N+]([O-])=O)=C[C:43]=1C(O)=O.C(NC1CCCCC1)C=C>>[CH2:1]([N:4]([CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1)[C:5](=[O:34])[C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH:20]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:14][CH2:13]2)[CH:9]=[CH:8][C:7]=1[CH:42]([CH3:50])[CH3:43])[CH:2]=[CH2:3]

Komponenten

4

Edukt 3

HCID 81115N-AllylcyclohexylamineHCID 2809972-Fluoro-5-nitrobenzoic acidHCID 22180389n-Allyl-n-cyclohexyl-5-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-2-fluorobenzamide

Produkt 1

HCID 22180348n-Allyl-n-cyclohexyl-5-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-2-isopropylbenzamide

Versuchsvorschrift

Steps (a) and (b) of Example 59 were repeated, except that the compound prepared just above in step (a) was used instead of 2-fluoro-5-nitrobenzoic acid. Step (d) of Example 1 was then repeated, except that N-allylcyclohexylamine was used instead of N-methylbenzylamine. Thus, the title compound was prepared.

Aufarbeitung

  1. customprepared just above in step (a)

Quellen und Nachweise

ORD-Eintrag
ord-733578ac9520400c95221efaf98025ec
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06777414B1

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