7-piperazinyl-2-(pyridin-2-yl)methyl-2H-phthalazin-1-one → 2-(Pyridin-2-yl)methyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]piperazin-1-yl]-2H-phthalazin-1-one

HRID 1836845Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1836845
[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23]Br)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[N:27]1([C:33]2[CH:42]=[C:41]3[C:36]([CH:37]=[N:38][N:39]([CH2:44][C:45]4[CH:50]=[CH:49][CH:48]=[CH:47][N:46]=4)[C:40]3=[O:43])=[CH:35][CH:34]=2)[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[N:46]1[CH:47]=[CH:48][CH:49]=[CH:50][C:45]=1[CH2:44][N:39]1[N:38]=[CH:37][C:36]2[C:41](=[CH:42][C:33]([N:27]3[CH2:32][CH2:31][N:30]([CH2:23][CH2:22][CH2:21][C:7]4([C:5](=[O:6])[NH:4][CH2:3][C:2]([F:26])([F:25])[F:1])[C:20]5[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=5[O:14][C:13]5[C:8]4=[CH:9][CH:10]=[CH:11][CH:12]=5)[CH2:29][CH2:28]3)=[CH:34][CH:35]=2)[C:40]1=[O:43]

Komponenten

3

Edukt 2

HCID 221802937-piperazinyl-2-(pyridin-2-yl)methyl-2H-phthalazin-1-oneHCID 221805833-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl bromide

Produkt 1

HCID 221804552-(Pyridin-2-yl)methyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]piperazin-1-yl]-2H-phthalazin-1-one

Versuchsvorschrift

Step (b) of Example 92 was repeated, except that the compound prepared in step (b) of Example 114 and the compound prepared in step (c) of Example 143 were used as the starting compounds. Thus, the title compound was obtained.

Quellen und Nachweise

ORD-Eintrag
ord-a40d9e1625fd4ebcb16a1195d112489d
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06777414B1

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