Sodium Hydroxide → 4-Amino-3-chloro-6-(3,4-dimethylphenyl)-pyridine-2-carboxylic acid

HRID 1837457Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1837457
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([CH3:15])[CH:9]=2)[N:5]=[C:4]([C:16]([O:18]C)=[O:17])[C:3]=1[Cl:20].[OH-].[Na+]>CO>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([CH3:15])[CH:9]=2)[N:5]=[C:4]([C:16]([OH:18])=[O:17])[C:3]=1[Cl:20]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 22677522Methyl 4-amino-3-chloro-6-(3,4-dimethylphenyl)pyridine-2-carboxylate

Produkt 1

HCID 226773054-Amino-3-chloro-6-(3,4-dimethylphenyl)-pyridine-2-carboxylic acidAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 4-amino-3-chloro-6-(3,4-dimethylphenyl)pyridine-2-carboxlate (0.9 g, 0.003 mol) was heated at reflux in methanol (50 mL) and 1N sodium hydroxide (75 mL) for two hours. The reaction mixture was partially concentrated and then acidified with concentrated hydrochloric acid. The solid was collected and dried to give 4-amino-3-chloro-6-(3,4-dimethylphenyl)-pyridine-2-carboxylic acid (0.85 g, 0.003 mol), mp 192-4° C.

Aufarbeitung

  1. concentrationThe reaction mixture was partially concentrated
  2. customThe solid was collected
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-be64961cd2634ce8a8040f6af51430eb
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06784137B2

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