4-Chloro-5-methylthieno[2,3-d]pyrimidine → 4-[2-Methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]-5-methylthieno[2,3-d]pyrimidine

HRID 1837471Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1837471
[NH2:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8].Cl[C:25]1[C:26]2[C:33]([CH3:34])=[CH:32][S:31][C:27]=2[N:28]=[CH:29][N:30]=1>C(O)(C)C>[CH3:8][C:7]1[CH:6]=[CH:5][C:4]([NH:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[CH:13]=2)=[O:11])=[CH:3][C:2]=1[NH:1][C:25]1[C:26]2[C:33]([CH3:34])=[CH:32][S:31][C:27]=2[N:28]=[CH:29][N:30]=1

Komponenten

4

Edukt 2

HCID 2902254-Chloro-5-methylthieno[2,3-d]pyrimidineHCID 17904941N-(3-amino-4-methylphenyl)-2-morpholinopyridine-4-carboxamide

Produkt 1

HCID 99121024-[2-Methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]-5-methylthieno[2,3-d]pyrimidineAusbeute 25,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
88 °C

Versuchsvorschrift

N-(3-amino-4-methylphenyl)-2-morpholinopyridine-4-carboxamide (0.056 g), 4-chloro-5-methylthieno[2,3-d]pyrimidine (Maybridge Chemical Company, Trevillet, Tintagel, Cornwall, PL34 0HW, GB; 0.037 g) and isopropanol (2 ml) and the reaction mixture was stirred and heated to 88° C. for 18 hours. The reaction mixture was cooled to ambient temperature and the precipitate was isolated and washed in turn with isohexane and diethyl ether. There was thus obtained the title compound (0.021 g); Mass: M+H+ 461.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. customthe precipitate was isolated
  3. washwashed in turn with isohexane and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-9ee3689c8f5440d0a2f65b0cd3e41f3d
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06784174B1

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