Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetate → Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl]-4-piperidyl]acetate

HRID 1837698Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1837698
[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][C:13](=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1.[H][H]>C(OCC)(=O)C.[C].[Pd]>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1

Komponenten

5

Edukt 2

HCID 22678611Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 22678708Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl]-4-piperidyl]acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2.6 g of ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetate and 380 mg of 10% palladium-carbon powder (water-containing product) were suspended in 20 ml of ethyl acetate. After replacing the atmosphere of a container with hydrogen, the mixture was stirred at room temperature under normal pressure for one hour. The reaction solution was filtered, and the filtrate was evaporated, to give the title compound as a yellow oil (quantitatively).

Aufarbeitung

  1. filtrationThe reaction solution was filtered
  2. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-dbcbbeefeab445ea88f19733d65a9076
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06784192B2

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