Hydrochloric Acid → HCID 22678413, Verbindung

HRID 1837712Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1837712
C[O:2][CH:3](OC)[C:4]1[C:5]([O:14][CH3:15])=[N:6][CH:7]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:9]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH3:13][S:10]([C:8]1[CH:9]=[C:4]([CH:3]=[O:2])[C:5]([O:14][CH3:15])=[N:6][CH:7]=1)(=[O:12])=[O:11]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 22678645HCID 22678645, Verbindung

Produkt 1

HCID 22678413HCID 22678413, VerbindungAusbeute 92,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

0.81 g of 5-(methylsulfonyl)-2-methoxy-3-pyridinecarboxaldehyde dimethyl acetal was dissolved in 8 ml of acetone, 2 ml of 5N-hydrochloric acid was added thereto, and the mixture was stirred at room temperature for 30 minutes. An aqueous sodium carbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, n-hexane was added to the residue and the resulting product was collected by filtration, to give 0.62 g of the title compound as a white powder.

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated
  5. additionn-hexane was added to the residue
  6. filtrationthe resulting product was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-00123e3a36254d27ad27ebb74abdefbf
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06784192B2

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