Hydrochloric Acid → 2-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)ethanamine dihydrochloride
Reaktionsgleichung
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[CH2:16][CH2:15][CH2:14][NH:13][C:12]=2[N:11]=1)(C)(C)C.[ClH:21]>CCOC(C)=O>[ClH:21].[ClH:21].[N:11]1[C:12]2[NH:13][CH2:14][CH2:15][CH2:16][C:17]=2[CH:18]=[CH:19][C:10]=1[CH2:9][CH2:8][NH2:7]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Through a solution of 10-6 (4.0 g, 16 mmol) in EtOAc (200 mL) at 0° C. was bubbled a stream of HCl gas for 10 minutes. After an additional 30 minutes, the mixture was purged with argon for 1 h and then concentrated. The residue was dissolved in acetonitrile and concentrated to give 10-7 as a yellow solid.
Aufarbeitung
- customthe mixture was purged with argon for 1 h
- concentrationconcentrated
- dissolutionThe residue was dissolved in acetonitrile
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-66fa16788d094482bff11acc88cf8512
- Quelldatensatz
- uspto-grants-2004_08
- Patentnummer
- US06784190B2
Notizen zur Reaktion
Wird geladen…