Methylamine → N-Methyl-2-(p-tolyl)ethanamine

HRID 1838920Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1838920
[CH3:1][NH2:2].S(C1C=CC(C)=CC=1)(O[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)(=O)=O>O1CCCC1>[CH3:1][NH:2][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 6329Methylamine2×HCID 2853862-(4-Methylphenyl)ethyl 4-methylbenzenesulfonate

Produkt 1

HCID 22898654N-Methyl-2-(p-tolyl)ethanamineAusbeute 180,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

9.2 g of methylamine are condensed at −20° C. into a solution of 5.8 g of 2-p-tolylethyl tosylate in 15 ml of abs. tetrahydrofuran and the mixture is stirred overnight at room temperature in a pressure vessel. After the pressure vessel has been opened at −20° C., it is allowed to come to room temperature in order to allow excess methylamine to evaporate. The reaction solution is taken up in ether, washed with water and saturated sodium chloride solution, dried over magnesium sulphate and concentrated to dryness in vacuo. 5.39 g of methyl-(2-p-tolylethyl)amine are obtained, which is reacted further as a crude product.

Aufarbeitung

  1. customhas been opened at −20° C.
  2. customto come to room temperature in order
  3. customto evaporate
  4. washwashed with water and saturated sodium chloride solution
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b35780ae1b2b434e9cd9b2a11ab538f2
Quelldatensatz
uspto-grants-2004_01
Patentnummer
US06677324B1

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