Triethylamine → (2R)-Butan-2-YL methanesulfonate

HRID 1838948

Reaktionsgleichung

Reaktionsgleichung von HRID 1838948
[CH3:1][S:2]([O:5]S(C)(=O)=O)(=[O:4])=[O:3].[CH3:10][C@@H:11](O)[CH2:12][CH3:13].C(N(CC)CC)C>ClCCl>[CH3:1][S:2]([O:5][C@H:11]([CH3:10])[CH2:12][CH3:13])(=[O:4])=[O:3]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 81560Methanesulfonic anhydrideHCID 84682(-)-2-Butanol

Produkt 1

HCID 148500(2R)-Butan-2-YL methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of methanesulphonic anhydride (8.33 g, 47.8 mmol) in dichloromethane (30 ml) was added dropwise over 30 minutes to an ice-cooled solution of (R)-2-butanol (4.0ml, 43.5 mmol) and triethylamine (6.65 ml, 47.8 mmol) in dichloromethane (70 ml). The reaction was then allowed to warm to room temperature and stirred for 18 hours. The mixture was then washed with water, 2N hydrochloric acid, then dried (Na2SO4) and evaporated under reduced pressure to give the title compound as a pale yellow oil, 7.0 g.

Aufarbeitung

  1. washThe mixture was then washed with water, 2N hydrochloric acid
  2. dry with materialdried (Na2SO4)
  3. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c666a9cb353045a88b0d68fbaf799a5a
Quelldatensatz
uspto-grants-2004_01
Patentnummer
US06677335B1

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