Ammonia methanol → 7-Sulfamoylimidazo[5,1-b]thiazole
Reaktionsgleichung
[NH3:1].CO.Cl[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])=[O:6]>C1COCC1>[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])(=[O:6])[NH2:1]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A 2 M ammonia/methanol solution, (4 ml) was added to a solution of 0.44 g of 7-chlorosulfonylimidazo[5,1-b]thiazole in 10 ml of THF. The mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated. The residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1) to give 0.34 g of 7-sulfamoylimidazo[5,1-b]thiazole.
Aufarbeitung
- concentrationThe reaction mixture was concentrated
- customThe residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1)
Quellen und Nachweise
- ORD-Eintrag
- ord-a54c390459e14ef497080825af863b89
- Quelldatensatz
- uspto-grants-2004_01
- Patentnummer
- US06677331B2
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