Ethyl Acetate → 1-(Ethoxycarbonyloxy)ethyl (1s,5r,6s)-2-(7-acetylimidazo[5,1-b]thiazol-2-yl)-6 ((1r)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate

Temperatur

-10 °C

Sodium (1S,5R,6S)-2-(7-acetylimidazo[5,1-b]thiazol-2-yl)-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate (71.9 mg) was dissolved in 2.0 ml of DMF. 1-(Ethoxycarbonyloxy)ethyl iodide (66.3 mg) was added to the solution in an argon atmosphere at −20° C. The mixture was stirred for 2 hr while raising the temperature to −10° C. Ethyl acetate (20 ml) was added to the reaction solution. The mixture was extracted twice, followed by washing twice with 10 ml of semisaturated brine. The organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under the reduced pressure to a volume of 2 ml. The residue was purified by column chromatography on silica gel (chloroform:methanol=15:1) and Sephadex LH-20 (dichloromethane:methanol=1:1) in that order to give 57.4 mg of the title compound.

1. extractionThe mixture was extracted twice
2. washby washing twice with 10 ml of semisaturated brine
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationThe filtrate was concentrated under the reduced pressure to a volume of 2 ml
6. customThe residue was purified by column chromatography on silica gel (chloroform:methanol=15:1) and Sephadex

ORD-Eintrag

ord-07b7381798574007b554313996fd0fdd

Quelldatensatz

uspto-grants-2004_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06677331B2