Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

HRID 1840284Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1840284
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1

Komponenten

3

Edukt 2

HCID 260Hydrogen BromideHCID 2735754HCID 2735754, Verbindung

Produkt 1

HCID 234479081-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

Versuchsvorschrift

A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature, the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p. >270° C. (ethanol).

Aufarbeitung

  1. temperatureat reflux for 30 hours
  2. filtrationthe mixture was filtered by suction
  3. washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound

Quellen und Nachweise

ORD-Eintrag
ord-7fe13fab2df94984b9a2a5dea6bc4f53
Quelldatensatz
uspto-grants-2004_01
Patentnummer
US06680319B2

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