Benzyl Bromide → 3-Phenyl-5-(3-phenylpropyl)isoxazole-4-carboxylic acid

HRID 1840304

Reaktionsgleichung

Reaktionsgleichung von HRID 1840304
[C:1]1([C:7]2[C:11]([C:12]([OH:14])=[O:13])=[C:10]([CH2:15][CH2:16]C3C=CC=CC=3)[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:1]1([C:7]2[C:11]([C:12]([OH:14])=[O:13])=[C:10]([CH2:15][CH2:16][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

3

Edukt 2

HCID 7498Benzyl BromideHCID 234479063-Phenyl-5-(2-phenylethyl)isoxazole-4-carboxylic acid

Produkt 1

HCID 234478873-Phenyl-5-(3-phenylpropyl)isoxazole-4-carboxylic acidAusbeute 72 %

Versuchsvorschrift

The title compound was prepared as described for Compound 28A but substituting 2-phenylethylbromide for benzyl bromide. The crude was purified by flash chromatography (ethyl acetate-petroleum ether-acetic acid 1:1:0.01 mL) to afford the title compound (72%).

Aufarbeitung

  1. customThe title compound was prepared
  2. customThe crude was purified by flash chromatography (ethyl acetate-petroleum ether-acetic acid 1:1:0.01 mL)

Quellen und Nachweise

ORD-Eintrag
ord-168ab362c36b44b29c13146257c680bf
Quelldatensatz
uspto-grants-2004_01
Patentnummer
US06680319B2

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