Piperidine → 3-(1H-indol-2-ylmethylene)-4-methyl-1,3-dihydroindol-2-one
Reaktionsgleichung
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:11])[NH:6]2.[NH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[C:13]1[CH:21]=O.N1CCCCC1>C(O)C>[NH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[C:13]1[CH:21]=[C:4]1[C:3]2[C:7](=[CH:8][CH:9]=[CH:10][C:2]=2[CH3:1])[NH:6][C:5]1=[O:11]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 95 °C
Versuchsvorschrift
A mixture of 4-methyl-2-oxindole (147 mg), indole-2-carbaldehyde (174 mg) (prepared according to Synthetic Communications, 1993, 23, 3109) and piperidine (10 mg) in ethanol was heated in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in vacuum oven for overnight to give 3-(1H-indol-2-ylmethylene)-4-methyl-1,3-dihydro-indol-2-one.
Aufarbeitung
- temperatureThe mixture was cooled to room temperature
- filtrationThe solid was collected by vacuum filtration
- washwashed with cold ethanol
- customdried in vacuum oven for overnight
Quellen und Nachweise
- ORD-Eintrag
- ord-cdb528b386884eb7b0ee51c1ea765940
- Quelldatensatz
- uspto-grants-2004_01
- Patentnummer
- US06680335B2
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