3-(2-Thienyl)acrylic acid → (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(2-thienyl)propenamide]
Reaktionsgleichung
Cl.Cl.[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH2:11])[CH2:4]2.[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1/[CH:17]=[CH:18]/[C:19](O)=[O:20]>>[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH:11][C:19](=[O:20])/[CH:18]=[CH:17]/[C:13]1[S:12][CH:16]=[CH:15][CH:14]=1)[CH2:4]2Komponenten
3
Versuchsvorschrift
Prepared as a free base by a method analogous to that described in Example 1 from (R)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(2-thienyl)propenoic acid; the compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent; MS (ES+) 263 (MH+).
Aufarbeitung
- customPrepared as a free base by a method analogous to
- customthe compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent