2-Furanacrylic acid → (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(2-furyl)propenamide]

HRID 1840917

Reaktionsgleichung

Reaktionsgleichung von HRID 1840917
Cl.Cl.[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@H:5]([NH2:11])[CH2:4]2.[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1/[CH:17]=[CH:18]/[C:19](O)=[O:20]>>[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@H:5]([NH:11][C:19](=[O:20])/[CH:18]=[CH:17]/[C:13]1[O:12][CH:16]=[CH:15][CH:14]=1)[CH2:4]2

Komponenten

3

Edukt 2

HCID 6434022-Furanacrylic acidHCID 12494973(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride

Produkt 1

HCID 20613779(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(2-furyl)propenamide]

Versuchsvorschrift

Prepared as a free base by a method analogous to that described in Example 1 from (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(2-furyl)propenoic acid; the compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent, followed by recrystallization from ethyl acetate/hexane; MS (ES+) 247 (MH+).

Aufarbeitung

  1. customPrepared as a free base by a method analogous to
  2. customthe compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent
  3. customfollowed by recrystallization from ethyl acetate/hexane

Quellen und Nachweise

ORD-Eintrag
ord-5eeea2a48aad4348bbcbd8f09047b1b8
Quelldatensatz
uspto-grants-2004_01
Patentnummer
US06683090B1

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