3-Bromo-5-(2-methyl-imidazol-1-ylmethyl)-pyridine → 3-(3-Chloro-4-methyl-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine hydrochloride
Reaktionsgleichung
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH3:14])[CH:7]=1.[Cl:15][C:16]1[CH:17]=[C:18](B2OC(C)(C)C(C)(C)O2)[CH:19]=[CH:20][C:21]=1[CH3:22]>>[ClH:15].[Cl:15][C:16]1[CH:17]=[C:18]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]3[CH:13]=[CH:12][N:11]=[C:10]3[CH3:14])[CH:7]=2)[CH:19]=[CH:20][C:21]=1[CH3:22]Komponenten
3
Versuchsvorschrift
The title compound, MS: m/e=298.3 (M+H+) was obtained as a beige solid (78% yield) by the reaction of 3-bromo-5-(2-methyl-imidazol-1-yl-methyl)-pyridine with 2-(3-chloro-4-methyl-phenyl)-4,4,5,5-tetramethyl[1,3,2]-dioxaborolane.
Quellen und Nachweise
- ORD-Eintrag
- ord-d85e3fe7fa614275832ec45bcf83c846
- Quelldatensatz
- uspto-grants-2004_01