Diisobutylaluminumhydride → HCID 23445089, Verbindung
Reaktionsgleichung
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][N:12]=2)[CH:10]=1)=O)C.[H-].C([Al+]CC(C)C)C(C)C>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([N:9]2[CH:10]=[C:6]([CH2:4][OH:3])[N:7]=[CH:8]2)=[N:12][CH:13]=1Komponenten
3
Versuchsvorschrift
Following the general method described in example 388, 1-(5-chloro-pyridin-2-yl)-1H-imidazole-4-carboxylic acid ethyl ester was reacted with diisobutylaluminum hydride. After hydrolytic workup and chromatography the title compound was obtained as a light brown crystalline solid. Mp. 82-87° C. (AcOEt/Et2O), MS: m/e=210 (M+H+).
Quellen und Nachweise
- ORD-Eintrag
- ord-f1629d9ae9574b1c93b19ae3db64530d
- Quelldatensatz
- uspto-grants-2004_01
- Patentnummer
- US06683097B2
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