Sodium hydride → 1-[(2-Methoxyquinoxalin-3-yl)N-isopropylaminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazine

HRID 1841485Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1841485
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[C:24]([O:30][CH3:31])[CH:23]=3)[CH2:18][CH2:17]2)=[O:15])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[H-].[Na+].[CH2:34](I)[CH2:35][CH3:36]>CN(C)C=O>[CH3:1][O:2][C:3]1[C:12]([N:13]([CH:35]([CH3:36])[CH3:34])[C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[C:24]([O:30][CH3:31])[CH:23]=3)[CH2:18][CH2:17]2)=[O:15])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 98669701-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazine

Produkt 1

HCID 234463001-[(2-Methoxyquinoxalin-3-yl)N-isopropylaminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazineAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To 1-[(2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazine (216 mg, 0.51 mmol) dissolved in dimethylformamide (20 ml), 60% sodium hydride (20.4 mg, 0.51 mmol) was added and stirred at room temperature for 15 minutes, and thereto propyl iodide (86.7 mg, 0.51 mmol) was added. The resulting mixture was stirred at room temperature for 6 hours, concentrated under the reduced pressure to remove the solvent and purified by column chromatography to obtain the titled compound.

Aufarbeitung

  1. stirringThe resulting mixture was stirred at room temperature for 6 hours
  2. concentrationconcentrated under the reduced pressure
  3. customto remove the solvent
  4. custompurified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-beb80fc91dc9436fa2a92293577a49e1
Quelldatensatz
uspto-grants-2004_01
Patentnummer
US06683184B2

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