Hydrochloric Acid → Methyl 4-methylpiperidine-4-carboxylate hydrochloride
Reaktionsgleichung
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH3:17])([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:18].[CH3:19]O>>[ClH:18].[CH3:19][O:16][C:14]([C:11]1([CH3:17])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15]Komponenten
4
Versuchsvorschrift
To a stirred solution of 4-methyl-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (1.00 g, 4.10 mmol) in MeOH (2 mL) is added HCl (5 ml, 4 M in dioxane). After 18 h, the mixture is evaporated to dryness, the residue is dissolved in MeOH (3 mL), and the stirred solution is treated with Et2O (45 ml). The resulting solid is filtered and dried to give the title compound.
Aufarbeitung
- customthe mixture is evaporated to dryness
- dissolutionthe residue is dissolved in MeOH (3 mL)
- additionthe stirred solution is treated with Et2O (45 ml)
- filtrationThe resulting solid is filtered
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-b6418eab5117486b93060a13a91ce257
- Quelldatensatz
- uspto-grants-2015_02
- Patentnummer
- US08946203B2
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