Cesium carbonate → Ethyl 5-(cyclopropylmethyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate

HRID 1842471Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1842471
[CH:1]1([CH2:4]Br)[CH2:3][CH2:2]1.[O:6]=[C:7]1[NH:12][CH2:11][CH2:10][N:9]2[N:13]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:15]=[C:8]12.C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[CH:1]1([CH2:4][N:12]2[CH2:11][CH2:10][N:9]3[N:13]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:15]=[C:8]3[C:7]2=[O:6])[CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 10796Cesium carbonateHCID 81503BromomethylcyclopropaneHCID 42873667Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrazine-2-carboxylate

Produkt 1

HCID 58465837Ethyl 5-(cyclopropylmethyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of cyclopropylmethyl bromide (0.101 g, 0.75 mmol) and ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (31.4 mg, 0.150 mmol) in acetonitrile (2 mL) was added cesium carbonate (147 mg, 0.45 mmol). The reaction mixture was heated overnight at 70° C. Upon cooling to room temperature, the insolubles were removed by filtration and the solvent evaporated to dryness to afford crude Intermediate 33.

Aufarbeitung

  1. temperatureUpon cooling to room temperature
  2. customthe insolubles were removed by filtration
  3. customthe solvent evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-df742b2d93744e508a5331f72e5a87af
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946223B2

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