2-(Acetoxymethyl)-3-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)phenylboronic Acid Pinacol Ester → (25)-(2-{4,4-Dimethyl-9-oxo-1,10-diazatricyclo-[6.4.0.02,6]dodeca-2(6),7-dien-10-yl}-4-fluoro-6-[1-methyl-5-({5-[2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]phenyl)-methyl acetate

Reaktionsgleichung

[C:1]([O:4][CH2:5][C:6]1[C:11]([N:12]2[CH2:24]CC3N4C(CCCC4)=CC=3[C:13]2=[O:25])=[CH:10][C:9]([F:26])=[CH:8][C:7]=1[C:27]1[CH:32]=[C:31]([NH:33][C:34]2[CH:39]=[CH:38][C:37]([N:40]3[CH2:45][CH2:44][N:43]([CH:46]4[CH2:49][O:48][CH2:47]4)[CH2:42][C@@H:41]3[CH3:50])=[CH:36][N:35]=2)[C:30](=[O:51])[N:29]([CH3:52])[CH:28]=1)(=[O:3])[CH3:2].C(OCC1C(B2OC(C)(C)C(C)(C)O2)=CC=CC=1N1C[CH2:83][N:82]2[C:75](=[CH:76][C:77]3[CH2:78][C:79]([CH3:86])([CH3:85])[CH2:80][C:81]=32)C1=O)(=O)C.BrC1C=C(NC2C=CC(N3CCN(C4COC4)C[C@@H]3C)=CN=2)C(=O)N(C)C=1>>[C:1]([O:4][CH2:5][C:6]1[C:7]([C:27]2[CH:32]=[C:31]([NH:33][C:34]3[CH:39]=[CH:38][C:37]([N:40]4[CH2:45][CH2:44][N:43]([CH:46]5[CH2:47][O:48][CH2:49]5)[CH2:42][C@@H:41]4[CH3:50])=[CH:36][N:35]=3)[C:30](=[O:51])[N:29]([CH3:52])[CH:28]=2)=[CH:8][C:9]([F:26])=[CH:10][C:11]=1[N:12]1[CH2:24][CH2:83][N:82]2[C:75](=[CH:76][C:77]3[CH2:78][C:79]([CH3:86])([CH3:85])[CH2:80][C:81]=32)[C:13]1=[O:25])(=[O:3])[CH3:2]