3-(N,N-Dimethylsulphonamido)benzeneboronic acid → 3-(2-{[dihydroxy(1-methylethyl)-lambda4-sulfanyl]amino}-2,3-dihydro-1H-inden-5-yl)-N,N-dimethylbenzenesulfonamide

HRID 18434

Reaktionsgleichung

Reaktionsgleichung von HRID 18434
I[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([NH:11][S:12]([CH:15]([CH3:17])[CH3:16])(=[O:14])=[O:13])[CH2:5]2.[CH3:18][N:19]([CH3:32])[S:20]([C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1)(=[O:22])=[O:21]>>[OH:13][S:12]([NH:11][CH:6]1[CH2:5][C:4]2[C:8](=[CH:9][CH:10]=[C:2]([C:25]3[CH:24]=[C:23]([S:20]([N:19]([CH3:32])[CH3:18])(=[O:21])=[O:22])[CH:28]=[CH:27][CH:26]=3)[CH:3]=2)[CH2:7]1)([OH:14])[CH:15]([CH3:17])[CH3:16]

Komponenten

3

Edukt 2

HCID 441196343-(N,N-Dimethylsulphonamido)benzeneboronic acidHCID 46899809N-(5-iodo-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide

Produkt 1

HCID 684475693-(2-{[dihydroxy(1-methylethyl)-lambda4-sulfanyl]amino}-2,3-dihydro-1H-inden-5-yl)-N,N-dimethylbenzenesulfonamide

Versuchsvorschrift

The title compound was prepared from N-(5-iodo-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide and {3-[(dimethylamino)sulfonyl]phenyl}boronic acid (WO2003004472) in a similar manner to Example 1.

Quellen und Nachweise

ORD-Eintrag
ord-42b9c346e4594c3b87f17142402350a2
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741351B2

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