Phosphorus oxide (P4O10) → 7-Bromo-3,4-dihydroisoquinolin-1(2H)-one
Reaktionsgleichung
C([O:3][C:4](=O)[NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][CH:9]=1)C.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>O=P(Cl)(Cl)Cl>[Br:14][C:11]1[CH:12]=[C:13]2[C:8]([CH2:7][CH2:6][NH:5][C:4]2=[O:3])=[CH:9][CH:10]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Using analogous reaction conditions and workup as described in Example 1, step 4, [2-(4-bromo-phenyl)-ethyl]-carbamic acid ethyl ester (I-3c: 5 g, 0.01838 mmol) in POCl3 (20 mL) was reacted with P2O5 (5.2 g, 0.03676 mmol) to afford the crude product. Purification by column chromatography on silica gel (50% ethylacetate in hexane) afforded 500 mg of the product (12% yield).
Aufarbeitung
- customreaction conditions and workup
- customto afford the crude product
- customPurification by column chromatography on silica gel (50% ethylacetate in hexane)
Quellen und Nachweise
- ORD-Eintrag
- ord-fe6c5c902ed74a1aa516865fe1825258
- Quelldatensatz
- uspto-grants-2015_02
- Patentnummer
- US08946260B2
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