Phosphorus oxide (P4O10) → 3,4-dihydro-5-methoxy-1(2H)-isoquinolinone

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Using the same procedure and workup as described in example 1, step 4, [2-(2-methoxy-phenyl)-ethyl]-carbamic acid ethyl ester (I-13c: 0.9 g, 0.0040 mmol) in POCl3 (5 mL) was reacted with P2O5 (1.19 g, 0.0084 mmol). The resulting mixture was stirred at 110° C. for 3 hours to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3) afforded 90 mg of the product (12.8% yield).

Herkunft & Nachweise