1,2-Diaminocyclohexane, trans- → 7-Trifluoromethyl-2-(4-trifluoromethyl-pyridin-3-yl)-3,4-dihydro-2H-isoquinolin-1-one

Beteiligte Stoffe

Reaktionsschritte

Using analogous reaction conditions as described in Example 1, 7-trifluoromethyl-3,4-dihydro-2H-isoquinolin-1-one (I-16c: 150 mg, 0.684 mmol) was reacted with 3-bromo-4-trifluoromethyl-pyridine (154.7 mg, 0.684 mmol), 1,4-dioxane (5 mL), copper iodide (12.96 mg, 0.0684 mmol), trans-1,2-diamino cyclohexane (23.39 mg, 0.2084 mmol) and potassium phosphate (434.6 mg, 2.05 mmol) to afford the crude product. Purification by preparative HPLC afforded 16 mg of the product (6.5% yield).

Herkunft & Nachweise