N,N,2-trimethyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-amine → 1-[2-(Dimethylamino)-2-methylpropyl]-1H-pyrazol-3-amine

HRID 1844539Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1844539
[CH3:1][N:2]([CH3:15])[C:3]([CH3:14])([CH3:13])[CH2:4][N:5]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[N:6]1>[C].[Pd].C(O)C.C(OCC)(=O)C>[CH3:1][N:2]([CH3:15])[C:3]([CH3:13])([CH3:14])[CH2:4][N:5]1[CH:9]=[CH:8][C:7]([NH2:10])=[N:6]1

Komponenten

4

Edukt 1

HCID 66880823N,N,2-trimethyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-amine

Produkt 1

HCID 583285031-[2-(Dimethylamino)-2-methylpropyl]-1H-pyrazol-3-amineAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 21584252Ethanol ethylacetateLösungsmittel

Versuchsvorschrift

N,N,2-trimethyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-amine (70.6 mg) was dissolved in a mixed solution (ethanol-ethyl acetate, 4:1, 5 mL). Then, 10% palladium-carbon (7 mg) was added to the prepared solution, and the solution was subjected to catalytic reduction at 101 kPa for about 2 hours. The reaction mixture was filtrated through Celite, and the filtrate was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (silica gel NH, ethyl acetate:hexane=1:1) to give the title compound as a yellow oil (56.8 mg, yield: 94%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtrated through Celite
  2. customthe filtrate was evaporated under reduced pressure
  3. customThe obtained residue was purified by silica gel column chromatography (silica gel NH, ethyl acetate:hexane=1:1)

Quellen und Nachweise

ORD-Eintrag
ord-7017e47eadb446ed878822deea378193
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946440B2

Notizen zur Reaktion

Wird geladen…