Chlorosulfonic acid → Methyl 2-[5-bromo-2-(chlorosulfonyl)phenyl]acetate

Reaktionsgleichung

[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1.[Cl:13][S:14](O)(=[O:16])=[O:15]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:14]([Cl:13])(=[O:16])=[O:15])=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:3]=1

Komponenten

Edukt 2

HCID 24638Chlorosulfonic acid

HCID 11746402Methyl 2-(3-bromophenyl)acetate

Produkt 1

HCID 90150774Methyl 2-[5-bromo-2-(chlorosulfonyl)phenyl]acetate

Versuchsvorschrift

Methyl 2-(3-bromophenyl)acetate (22 g, 67 mmol) was slowly added into ClSO3H at −10° C. After 1 h, the mixture was warmed up to rt and stirred overnight, diluted slowly with ice water and extracted with EA. The organic layer was washed with water, dried over Na2SO4 and evaporated to give compound P15a (17 g, 54%).

Aufarbeitung

extractionextracted with EA
washThe organic layer was washed with water
dry with materialdried over Na2SO4
customevaporated
customto give compound P15a (17 g, 54%)

Quellen und Nachweise

ORD-Eintrag: ord-6bdd0a8009b1423cbe5b959f58aecfca
Quelldatensatz: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08946446B2

Notizen zur Reaktion

Wird geladen…