Chloride → Methyl 4-chloro-3-(chlorosulfonyl)benzoate

HRID 1845147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1845147
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11]([Cl:14])(=[O:13])=[O:12].[Cl-].[CH3:16]O>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:16])=[O:7])=[CH:4][C:3]=1[S:11]([Cl:14])(=[O:12])=[O:13]

Komponenten

4

Edukt 3

HCID 312ChlorideHCID 887MethanolHCID 756134-Chloro-3-(chlorosulphonyl)benzoic acid

Produkt 1

HCID 18071846Methyl 4-chloro-3-(chlorosulfonyl)benzoate

Versuchsvorschrift

A round bottom flask was charged with 4-chloro-3-(chlorosulfonyl)benzoic acid (16.0 g, 63.24 mmol) and methanol (100 mL), and thinoyl chloride (9.3 mL, 126.5 mmol) was added slowly at 0° C. The reaction mixture was then heated to reflux for 1.5 hours. The volatiles were removed under reduced pressure, and the residue was diluted with water and extracted with EtOAc. The solvents were removed under reduced pressure to get the title compound as a solid.

Aufarbeitung

  1. additionwas added slowly at 0° C
  2. temperatureThe reaction mixture was then heated
  3. temperatureto reflux for 1.5 hours
  4. customThe volatiles were removed under reduced pressure
  5. additionthe residue was diluted with water
  6. extractionextracted with EtOAc
  7. customThe solvents were removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6f0667ae0f104694bb887cc47f59ed7c
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946439B2

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