Pyridine → 3-Iodo-2-methyl-5-(pyrrolidin-1-ylsulfonyl)benzoic acid

HRID 1845204Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1845204
Cl[S:2]([C:5]1[CH:6]=[C:7]([I:15])[C:8]([CH3:14])=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.N1C=CC=CC=1>O1CCOCC1>[I:15][C:7]1[C:8]([CH3:14])=[C:9]([CH:13]=[C:5]([S:2]([N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)(=[O:4])=[O:3])[CH:6]=1)[C:10]([OH:12])=[O:11]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 31268PyrrolidineHCID 581880135-(Chlorosulfonyl)-3-iodo-2-methylbenzoic acid

Produkt 1

HCID 581883403-Iodo-2-methyl-5-(pyrrolidin-1-ylsulfonyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A round bottom flask was charged with 5-(chlorosulfonyl)-3-iodo-2-methylbenzoic acid (1.00 g, 2.77 mmol), pyrrolidine (0.278 mL, 3.33 mmol), 1,4-dioxane (4 mL) and pyridine (0.20 mL, 2.5 mmol). The mixture was stirred for 30 minutes. The solvent was removed and the residue was purified by flash chromatography to yield the compound as a yellow solid.

Aufarbeitung

  1. customThe solvent was removed
  2. customthe residue was purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-21161e9b79f34633964e57838a671d76
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946439B2

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