Ethyl 5-(hydroxymethyl)-4'-methylbiphenyl-3-carboxylate → Ethyl 5-formyl-4'-methylbiphenyl-3-carboxylate

HRID 1845257Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1845257
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)[CH:8]=1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH:2]([C:3]1[CH:4]=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:6]=[C:7]([C:9]2[CH:10]=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=2)[CH:8]=1)=[O:1]

Komponenten

4

Edukt 1

HCID 58188190Ethyl 5-(hydroxymethyl)-4'-methylbiphenyl-3-carboxylate

Produkt 1

HCID 58188063Ethyl 5-formyl-4'-methylbiphenyl-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of ethyl 5-(hydroxymethyl)-4′-methylbiphenyl-3-carboxylate (400 mg, 1.5 mmol) and manganese(IV) oxide (660 mg, 6.6 mmol) in methylene chloride (14 mL) was stirred at room temperature overnight. The reaction mixture was filtered through Celite and washed with methylene chloride. The filtrate was concentrated to afford the title compound.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. washwashed with methylene chloride
  3. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-e35decb50e3d4e4d9d5307a8910fa373
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946439B2

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