Ethyl orthoformate → 4-Chloro-7-cyclobutyl-7H-imidazo[4,5-c]pyridazine
Reaktionsgleichung
[Cl:1][C:2]1[C:3]([NH2:13])=[C:4]([NH:8][CH:9]2[CH2:12][CH2:11][CH2:10]2)[N:5]=[N:6][CH:7]=1.[CH:14](OCC)(OCC)OCC>>[Cl:1][C:2]1[C:3]2[N:13]=[CH:14][N:8]([CH:9]3[CH2:12][CH2:11][CH2:10]3)[C:4]=2[N:5]=[N:6][CH:7]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 140 °C
Versuchsvorschrift
A mixture of 5-chloro-N3-cyclobutylpyridazin-3,4-diamine (Preparation 98, 140 mg, 0.70 mmol) and triethyl orthoformate (4 mL) was heated at 140° C. for 4 hours. After evaporation in vacuo, the crude residue was purified by silica gel column chromatography eluting with CH2Cl2:MeOH 99:1 to afford the title compound as an off white solid in 54% yield, 80 mg.