Trifluoroacetic acid → 6-Amino-4-methyl-1,3-benzoxazol-2(3H)-one

HRID 1846427Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846427
C(O)(C(F)(F)F)=O.[CH3:8][C:9]1[C:14]2[NH:15][C:16](=[O:18])[O:17][C:13]=2[CH:12]=[C:11]([NH:19]C(=O)OC(C)(C)C)[CH:10]=1>C(Cl)Cl>[NH2:19][C:11]1[CH:10]=[C:9]([CH3:8])[C:14]2[NH:15][C:16](=[O:18])[O:17][C:13]=2[CH:12]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67126852Tert-butyl (4-methyl-2-oxo-2,3-dihydro-benzoxazol-6-yl)-carbamate

Produkt 1

HCID 199116046-Amino-4-methyl-1,3-benzoxazol-2(3H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

400 μL (5.30 mmol) TFA were added to 230 mg (0.900 mmol) tert-butyl (4-methyl-2-oxo-2,3-dihydro-benzoxazol-6-yl)-carbamate in 5.0 ml DCM and the mixture was stirred for 1.5 h at RT. The reaction mixture was evaporated down and the residue was divided between semisaturated sodium hydrogen carbonate solution and EtOAc. The organic phase was dried on sodium sulphate, filtered and evaporated down.

Aufarbeitung

  1. customThe reaction mixture was evaporated down
  2. customThe organic phase was dried on sodium sulphate
  3. filtrationfiltered
  4. customevaporated down

Quellen und Nachweise

ORD-Eintrag
ord-baf8ec1fae1d465cbd77798864253e97
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952014B2

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